Type I interferon and proinflammatory cytokine levels in cerebrospinal fluid of newborns with rotavirus-associated leukoencephalopathy.
Brain Dev
; 40(3): 211-217, 2018 Mar.
Article
in En
| MEDLINE
| ID: mdl-29150375
ABSTRACT
OBJECTIVE:
The purpose of this study was to identify whether there is an increase in type I interferon and proinflammatory cytokine levels in the cerebrospinal fluid of newborns with rotavirus-associated leukoencephalopathy.METHODS:
Levels of type I interferons (interferon-alpha and interferon-beta) and proinflammatory cytokines (interleukin-6 and interferon-gamma) were measured in the cerebrospinal fluid of 23 newborns with rotavirus-associated leukoencephalopathy (patient group) and 39 infants under 90â¯days-of-age (control group).RESULTS:
Cerebrospinal fluid pleocytosis was not observed in either group. Cerebrospinal fluid interleukin-6 levels were significantly higher in the patient group (7.02⯱â¯5.88â¯pg/mL) than in the control group (1.14⯱â¯1.90â¯pg/mL) (pâ¯<â¯.0001). The mean cerebrospinal fluid interferon-gamma levels of the patient group (24.43⯱â¯40.16â¯pg/mL) were also significantly higher than those of the controls group (0.0⯱â¯0.0â¯pg/mL) (pâ¯<â¯.0001). Cerebrospinal fluid interferon-alpha was not detected in any patient (0%) from the patient group, but was detected in four (10.3%) of the controls. Interferon-beta was detected in only two patients (8.7%) from the patient group and in one (2.6%) of the controls. Cerebrospinal fluid interleukin-6 levels correlated positively with the extent of white matter lesions on diffusion-weighted magnetic resonance imaging (râ¯=â¯0.607, pâ¯=â¯.002).CONCLUSIONS:
Significant increases in proinflammatory cytokine levels accompanied by very low detection rates of type I interferon in cerebrospinal fluid indicate that rotavirus-associated leukoencephalopathy in newborns can be correlated with central nervous system inflammatory processes without direct virus invasion into the central nervous system.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rotavirus Infections
/
Interferon Type I
/
Cytokines
/
Leukoencephalopathies
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Newborn
Language:
En
Journal:
Brain Dev
Year:
2018
Document type:
Article