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The E3 ubiquitin ligase APC/CCdh1 degrades MCPH1 after MCPH1-ßTrCP2-Cdc25A-mediated mitotic entry to ensure neurogenesis.
Liu, Xiaoqian; Zong, Wen; Li, Tangliang; Wang, Yujun; Xu, Xingzhi; Zhou, Zhong-Wei; Wang, Zhao-Qi.
Affiliation
  • Liu X; Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena, Germany.
  • Zong W; Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena, Germany.
  • Li T; Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena, Germany.
  • Wang Y; Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, China.
  • Xu X; Division of Biology, City of Hope National Medical Center/Beckman Research Institute, Duarte, CA, USA.
  • Zhou ZW; Beijing Key Laboratory of DNA Damage Response, College of Life Sciences, Capital Normal University, Beijing, China.
  • Wang ZQ; Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University School of Medicine, Shenzhen, Guangdong, China.
EMBO J ; 36(24): 3666-3681, 2017 12 15.
Article in En | MEDLINE | ID: mdl-29150431
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cdc25 Phosphatases / Ubiquitin-Protein Ligases / Beta-Transducin Repeat-Containing Proteins / Neurogenesis / Nerve Tissue Proteins Limits: Animals / Humans Language: En Journal: EMBO J Year: 2017 Document type: Article Affiliation country: Germany Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cdc25 Phosphatases / Ubiquitin-Protein Ligases / Beta-Transducin Repeat-Containing Proteins / Neurogenesis / Nerve Tissue Proteins Limits: Animals / Humans Language: En Journal: EMBO J Year: 2017 Document type: Article Affiliation country: Germany Country of publication: United kingdom