Elimination profile of triamcinolone in urine following oral administration.
Drug Test Anal
; 10(5): 860-864, 2018 May.
Article
in En
| MEDLINE
| ID: mdl-29155490
ABSTRACT
Triamcinolone (T) is a glucocorticoid commonly used to relieve inflammation and treat arthritis, severe allergies, and asthma; however, it is banned by the World Anti-Doping Agency in competition for athletes when administered orally, intravenously, intramuscularly, or rectally. The minimum required performance limit (MRPL) for urinary T is 30 ng/mL. However, the data about the urinary excretion of T after oral administration is limited. We investigate the elimination profile and determine whether single-dose administration of T would cause a positive doping result. Twelve healthy volunteers received a single-dose of 4-mg T rally, and urine samples were collected for 24 hours. A validated liquid chromatography-tandem mass spectrometry method was used to determine urinary T levels. Non-compartmental modeling was used to estimate the pharmacokinetic parameters. All the urinary T concentrations were much higher than the MRPL. The peak urinary T concentration was 3211.4 ± 860.3 ng/mL (mean ± SD), time to peak concentration was 1.7 ± 0.9 hours, and the estimated elimination half-life was 4.4 ± 2.8 hours. About 27.76% of the consumed dose was eliminated via urine within 24 hours of intake. After a single-dose oral administration, urinary T concentrations still exceeded the MRPL after 24 hours. This information could be useful for limiting the misuse of T. Athletes should be aware when using T in competition and acquire approval for a therapeutic use exemption prior to use. Moreover, the elimination profile of orally administered T may be crucial information for distinguishing different dosage routes.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Triamcinolone
/
Substance Abuse Detection
/
Tandem Mass Spectrometry
/
Glucocorticoids
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Drug Test Anal
Journal subject:
FARMACOLOGIA
Year:
2018
Document type:
Article
Affiliation country:
Taiwan