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New Paradigms for the Study of Ocular Alphaherpesvirus Infections: Insights into the Use of Non-Traditional Host Model Systems.
Pennington, Matthew R; Ledbetter, Eric C; Van de Walle, Gerlinde R.
Affiliation
  • Pennington MR; Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. mrp244@cornell.edu.
  • Ledbetter EC; Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. ecl32@cornell.edu.
  • Van de Walle GR; Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. grv23@cornell.edu.
Viruses ; 9(11)2017 11 18.
Article in En | MEDLINE | ID: mdl-29156583
Ocular herpesviruses, most notably human alphaherpesvirus 1 (HSV-1), canid alphaherpesvirus 1 (CHV-1) and felid alphaherpesvirus 1 (FHV-1), infect and cause severe disease that may lead to blindness. CHV-1 and FHV-1 have a pathogenesis and induce clinical disease in their hosts that is similar to HSV-1 ocular infections in humans, suggesting that infection of dogs and cats with CHV-1 and FHV-1, respectively, can be used as a comparative natural host model of herpesvirus-induced ocular disease. In this review, we discuss both strengths and limitations of the various available model systems to study ocular herpesvirus infection, with a focus on the use of these non-traditional virus-natural host models. Recent work has demonstrated the robustness and reproducibility of experimental ocular herpesvirus infections in dogs and cats, and, therefore, these non-traditional models can provide additional insights into the pathogenesis of ocular herpesvirus infections.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Herpesviridae Infections / Disease Models, Animal / Dog Diseases / Eye Diseases / Models, Biological Limits: Animals Language: En Journal: Viruses Year: 2017 Document type: Article Affiliation country: United States Country of publication: Switzerland

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Herpesviridae Infections / Disease Models, Animal / Dog Diseases / Eye Diseases / Models, Biological Limits: Animals Language: En Journal: Viruses Year: 2017 Document type: Article Affiliation country: United States Country of publication: Switzerland