Castleman Disease Pathogenesis.
Hematol Oncol Clin North Am
; 32(1): 11-21, 2018 02.
Article
in En
| MEDLINE
| ID: mdl-29157613
ABSTRACT
Castleman disease (CD) describes a group of heterogeneous disorders with common lymph node histopathologic features, including atrophic or hyperplastic germinal centers, prominent follicular dendritic cells, hypervascularization, polyclonal lymphoproliferation, and/or polytypic plasmacytosis. The cause and pathogenesis of the four subtypes of CD (unicentric CD; human herpesvirus-8-associated multicentric CD; polyradiculoneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes [POEMS]-associated multicentric CD; and idiopathic multicentric CD) vary considerably. This article provides a summary of our current understanding of the cause, cell types, signaling pathways, and effector cytokines implicated in the pathogenesis of each subtype.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Signal Transduction
/
Cytokines
/
Castleman Disease
/
Herpesviridae Infections
/
Herpesvirus 8, Human
/
Lymph Nodes
/
Neoplasm Proteins
Type of study:
Etiology_studies
Limits:
Humans
Language:
En
Journal:
Hematol Oncol Clin North Am
Journal subject:
HEMATOLOGIA
/
NEOPLASIAS
Year:
2018
Document type:
Article
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA