Towards natural mimetics of metformin and rapamycin.

Aliper, Alexander; Jellen, Leslie; Cortese, Franco; Artemov, Artem; Karpinsky-Semper, Darla; Moskalev, Alexey; Swick, Andrew G; Zhavoronkov, Alex

Aliper, Alexander; Jellen, Leslie; Cortese, Franco; Artemov, Artem; Karpinsky-Semper, Darla; Moskalev, Alexey; Swick, Andrew G; Zhavoronkov, Alex.

Affiliation

Aliper A; Insilico Medicine, Inc, Research Department, Baltimore, MD 21218, USA.
Jellen L; Insilico Medicine, Inc, Research Department, Baltimore, MD 21218, USA.
Cortese F; Biogerontology Research Foundation, Research Department, Oxford, United Kingdom.
Artemov A; Department of Biomedical and Molecular Science, Queen's University School of Medicine, Queen's University, Kingston, ON K7L 3N6, Canada.
Karpinsky-Semper D; Insilico Medicine, Inc, Research Department, Baltimore, MD 21218, USA.
Moskalev A; Life Extension, Ft. Lauderdale, FL 33308, USA.
Swick AG; Laboratory of Molecular Radiobiology and Gerontology, Institute of Biology of Komi Science Center of Ural Branch of Russian Academy of Sciences, Syktyvkar, 167982, Russia.
Zhavoronkov A; Life Extension, Ft. Lauderdale, FL 33308, USA.

Aging (Albany NY) ; 9(11): 2245-2268, 2017 11 15.

Article in En | MEDLINE | ID: mdl-29165314

Subject(s)

Dietary Supplements; Drug Discovery/methods; High-Throughput Screening Assays; Metformin/pharmacology; Molecular Mimicry; Protein Kinase Inhibitors/pharmacology; Sirolimus/pharmacology; TOR Serine-Threonine Kinases/antagonists & inhibitors; Computational Biology; Databases, Genetic; Dietary Supplements/adverse effects; Dietary Supplements/classification; Gene Regulatory Networks/drug effects; Humans; Machine Learning; Metformin/adverse effects; Metformin/chemistry; Metformin/classification; Molecular Structure; Molecular Targeted Therapy; Neural Networks, Computer; Protein Interaction Maps/drug effects; Protein Kinase Inhibitors/adverse effects; Protein Kinase Inhibitors/chemistry; Protein Kinase Inhibitors/classification; Signal Transduction/drug effects; Sirolimus/adverse effects; Sirolimus/chemistry; Sirolimus/classification; Structure-Activity Relationship

Key words

compound screening; deep learning; geroprotector; metformin; natural; nutraceutical; rapamycin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Molecular Mimicry / Dietary Supplements / Sirolimus / Protein Kinase Inhibitors / Drug Discovery / High-Throughput Screening Assays / TOR Serine-Threonine Kinases / Metformin Type of study: Prognostic_studies Limits: Humans Language: En Journal: Aging (Albany NY) Journal subject: GERIATRIA Year: 2017 Document type: Article Affiliation country: United States Country of publication: United States

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