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Insight into partial agonism by observing multiple equilibria for ligand-bound and Gs-mimetic nanobody-bound ß1-adrenergic receptor.
Solt, Andras S; Bostock, Mark J; Shrestha, Binesh; Kumar, Prashant; Warne, Tony; Tate, Christopher G; Nietlispach, Daniel.
Affiliation
  • Solt AS; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK.
  • Bostock MJ; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK.
  • Shrestha B; Protein Sciences, CBT, Novartis Institutes for BioMedical Research (NIBR), CH-4002, Basel, Switzerland.
  • Kumar P; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK.
  • Warne T; Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge, CB2 0QH, UK.
  • Tate CG; Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge, CB2 0QH, UK.
  • Nietlispach D; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK. dn206@cam.ac.uk.
Nat Commun ; 8(1): 1795, 2017 11 27.
Article in En | MEDLINE | ID: mdl-29176642
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Receptors, Adrenergic, beta-2 / GTP-Binding Protein alpha Subunits, Gs / Single-Domain Antibodies Limits: Animals Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2017 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Receptors, Adrenergic, beta-2 / GTP-Binding Protein alpha Subunits, Gs / Single-Domain Antibodies Limits: Animals Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2017 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom