[Study on clinical management of HPV(+)/Pap(-) during cervical cancer screening].
Zhonghua Fu Chan Ke Za Zhi
; 52(11): 745-750, 2017 Nov 25.
Article
in Zh
| MEDLINE
| ID: mdl-29179269
ABSTRACT
Objective:
To study the clinical management way for HPV(+)/papanicolaou (Pap)(-) during cervical cancer screening.Methods:
To analyze retrospectively the data from the patients who had loop electrical excision procedure (LEEP) for biopsy confirmed cervical intraepithelial neoplasia (CIN) â ¡ in Peking University People's Hospital from Jan. 2010 to Dec. 2014.Results:
(1) For biopsy confirmed CIN â ¡, HPV positive rate was 98.5% (135/137), Pap test positive [≥atypical squamous cell of undetermined significance (ASCUS)] rate was 69.3% (95/137), there was significant difference between them (χ(2)=43.32, P<0.01). (2) For the 42 patients with HPV(+)/Pap(-), whose cytology slides were reviewed again. Among them, the interpretations of there were 16 cases confirmed as the same before, while 26 cases were changed to abnormal (≥ASCUS). Cytology be misdiagnosed was 19.0% (26/137) at the first review. Among the 26 cases, 13 (50.0%) cases were missed for the little amount of abnormal cells, 8 (30.8%) cases for mild atypical morphology changed; the other 5 (19.2%) cases missed for stain problems. (3) For the cervical LEEP samples, 37 cases of the pathology diagnosis were upgrade to CIN â ¢(+), among them, 2 cases of microinvasive cervical carcinoma, 1 case of invasive cancer, 34 cases of CIN â ¢; 37 cases were CINâ or no lesion found; 63 cases were still CIN â ¡. Four to six months later after LEEP, the cytology abnormal rate was 11.7% (16/137), and the HR-HPV positive rate was 34.3% (47/137).Conclusions:
Compared with cytology alone, cytology combined with HPV testing increase the sensitivity of cervical high grade lesion. For the cases of HPV(+)/Pap(-) cases, the cytology slides should be reviewed. The quality control of cervical exfoliate sample collection and interpretation should be strengthened. LEEP procedure is not only a treatment method, but also it could provide samples to confirm the diagnosis.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Papillomaviridae
/
Vaginal Smears
/
Uterine Cervical Dysplasia
/
Uterine Cervical Neoplasms
/
Papanicolaou Test
Type of study:
Diagnostic_studies
/
Observational_studies
/
Screening_studies
Limits:
Adult
/
Female
/
Humans
/
Middle aged
Language:
Zh
Journal:
Zhonghua Fu Chan Ke Za Zhi
Year:
2017
Document type:
Article
Affiliation country:
China