Photolabile ruthenium complexes to cage and release a highly cytotoxic anticancer agent.

Wei, Jianhua; Renfrew, Anna K

Wei, Jianhua; Renfrew, Anna K.

Affiliation

Wei J; School of Chemistry, University of Sydney, Sydney, NSW, Australia.
Renfrew AK; School of Chemistry, University of Sydney, Sydney, NSW, Australia. Electronic address: anna.renfrew@sydney.edu.au.

J Inorg Biochem ; 179: 146-153, 2018 02.

Article in En | MEDLINE | ID: mdl-29180165

Subject(s)

Antineoplastic Agents/pharmacology; Coordination Complexes/pharmacology; Cyanides/pharmacology; Guanidines/pharmacology; Prodrugs/pharmacology; Ruthenium/chemistry; A549 Cells; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/radiation effects; Coordination Complexes/chemical synthesis; Coordination Complexes/radiation effects; Cyanides/radiation effects; DNA/chemistry; Guanidines/radiation effects; Humans; Inhibitory Concentration 50; Light; MCF-7 Cells; Membrane Potential, Mitochondrial/drug effects; Prodrugs/chemical synthesis; Prodrugs/radiation effects; Reactive Oxygen Species/metabolism

Key words

Anticancer; Drug delivery; Photocaging; Prodrug; Ruthenium

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ruthenium / Prodrugs / Cyanides / Coordination Complexes / Guanidines / Antineoplastic Agents Limits: Humans Language: En Journal: J Inorg Biochem Year: 2018 Document type: Article Affiliation country: Australia Country of publication: United States

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