The effect of oxidative stress on the progression of Hashimoto's thyroiditis.
Arch Physiol Biochem
; 124(4): 351-356, 2018 Oct.
Article
in En
| MEDLINE
| ID: mdl-29185364
ABSTRACT
OBJECTIVE:
We aimed to investigate the effects of oxidative stress in the pathogenesis and progression of Hashimoto's thyroiditis (HT).METHODS:
Forty euthyroid and 40 subclinical hypothyroid patients older than 18 years and not yet had received treatment were enrolled in the study.RESULTS:
In the 9 months follow-up, 14 of the HT patients developed overt hypothyroidism. The mean total oxidant status (TOS) and oxidative stress index (OSI) were higher in patients who developed overt hypothyroidism than those who did not (p < .001). And no significant difference was found between the two groups in terms of paraoxanase-1 and arylesterase (p > .05). Multivariable Cox regression model showed thyroid stimulating hormone level (HR = 1.348, p < .001), free-thyroxine level (HR = 0.481, p = .017) and OSI ratio (HR = 2.349, p < .001) to be independent predictors of development of overt hypothyroidism. OSI level, being over 2.96 with 92.9% sensitivity and 62.5% specificity, predicts the risk of hypothyroidism.CONCLUSION:
Oxidative stress may be an effective risk factor in the development of overt hypothyroidism in HT.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thyroid Gland
/
Oxidative Stress
/
Hashimoto Disease
/
Asymptomatic Diseases
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Arch Physiol Biochem
Journal subject:
BIOQUIMICA
/
FISIOLOGIA
Year:
2018
Document type:
Article
Affiliation country:
Turkey
Publication country:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM