Metabolomic effects of CeO<sub>2</sub>, SiO<sub>2</sub> and CuO metal oxide nanomaterials on HepG2 cells.

Kitchin, Kirk T; Stirdivant, Steve; Robinette, Brian L; Castellon, Benjamin T; Liang, Xinhua

Metabolomic effects of CeO₂, SiO₂ and CuO metal oxide nanomaterials on HepG2 cells.

Kitchin, Kirk T; Stirdivant, Steve; Robinette, Brian L; Castellon, Benjamin T; Liang, Xinhua.

Affiliation

Kitchin KT; Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, 109 Alexander Drive, Mail Drop B105-03, Research Triangle Park, NC, 27711, USA. kitchin.kirk@epa.gov.
Stirdivant S; Metabolon, Inc., 107 Davis Drive, Suite 400, Research Triangle Park, NC, 27713, USA.
Robinette BL; Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, 109 Alexander Drive, Mail Drop B105-03, Research Triangle Park, NC, 27711, USA.
Castellon BT; Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, 109 Alexander Drive, Mail Drop B105-03, Research Triangle Park, NC, 27711, USA.
Liang X; Chemical and Biochemical Engineering, Missouri University of Science and Technology, 210A Bertelsmeyer Hall, 1101 N. State Street, Rolla, MO, 65409-1230, USA.

Part Fibre Toxicol ; 14(1): 50, 2017 11 29.

Article in En | MEDLINE | ID: mdl-29187207

Subject(s)

Cerium/toxicity; Chemical and Drug Induced Liver Injury/etiology; Copper/toxicity; Hepatocytes/drug effects; Metabolomics/methods; Metal Nanoparticles/toxicity; Silicon Dioxide/toxicity; Chemical and Drug Induced Liver Injury/metabolism; Chemical and Drug Induced Liver Injury/pathology; Chromatography, Liquid; Dose-Response Relationship, Drug; Energy Metabolism/drug effects; Gas Chromatography-Mass Spectrometry; Glucuronides/metabolism; Glutathione/metabolism; Hep G2 Cells; Hepatocytes/metabolism; Hepatocytes/pathology; Humans; Lipid Metabolism/drug effects; Methylation; Oxidation-Reduction; Oxidative Stress/drug effects; Particle Size; Time Factors

Key words

CeO2; CuO; Fatty acids; HepG2; Metabolomics; Nanomaterial; SiO2

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cerium / Silicon Dioxide / Copper / Hepatocytes / Metal Nanoparticles / Metabolomics / Chemical and Drug Induced Liver Injury Limits: Humans Language: En Journal: Part Fibre Toxicol Journal subject: TOXICOLOGIA Year: 2017 Document type: Article Affiliation country: United States Country of publication: United kingdom

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