Direct regulation of p190RhoGEF by activated Rho and Rac GTPases.

Dada, Olugbenga; Gutowski, Stephen; Brautigam, Chad A; Chen, Zhe; Sternweis, Paul C

Dada, Olugbenga; Gutowski, Stephen; Brautigam, Chad A; Chen, Zhe; Sternweis, Paul C.

Affiliation

Dada O; Department of Pharmacology, The University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA. Electronic address: gbengadada@outlook.com.
Gutowski S; Department of Pharmacology, The University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA. Electronic address: stephen.gutowski@utsouthwestern.edu.
Brautigam CA; Department of Biophysics, The University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA; Department of Microbiology, The University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA. Electronic address: chad.Brautigam@utsouthwester
Chen Z; Department of Biophysics, The University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA. Electronic address: zhe.chen@utsouthwestern.edu.
Sternweis PC; Department of Pharmacology, The University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA. Electronic address: paul.sternweis@utsouthwestern.edu.

J Struct Biol ; 202(1): 13-24, 2018 04.

Article in En | MEDLINE | ID: mdl-29196061

Subject(s)

Guanine Nucleotide Exchange Factors/chemistry; Protein Domains; rac GTP-Binding Proteins/chemistry; rhoA GTP-Binding Protein/chemistry; Amino Acid Sequence; Feedback, Physiological; Guanine Nucleotide Exchange Factors/genetics; Guanine Nucleotide Exchange Factors/metabolism; Guanosine 5'-O-(3-Thiotriphosphate)/chemistry; Guanosine 5'-O-(3-Thiotriphosphate)/metabolism; Humans; Models, Molecular; Protein Binding; Sequence Homology, Amino Acid; rac GTP-Binding Proteins/genetics; rac GTP-Binding Proteins/metabolism; rhoA GTP-Binding Protein/genetics; rhoA GTP-Binding Protein/metabolism

Key words

Crosstalk; Crystal structure; GTPase; Membrane localization; PH domain; RhoGEF

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rac GTP-Binding Proteins / RhoA GTP-Binding Protein / Guanine Nucleotide Exchange Factors / Protein Domains Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Struct Biol Journal subject: BIOLOGIA MOLECULAR Year: 2018 Document type: Article

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