Effect of milling on the plastic and the elastic stiffness of lactose particles.

Pazesh, Samaneh; Persson, Ann-Sofie; Berggren, Jonas; Alderborn, Göran

Pazesh, Samaneh; Persson, Ann-Sofie; Berggren, Jonas; Alderborn, Göran.

Affiliation

Pazesh S; Department of Pharmacy, Uppsala University, Uppsala, Sweden. Electronic address: samaneh.pazesh@farmaci.uu.se.
Persson AS; Department of Pharmacy, Uppsala University, Uppsala, Sweden.
Berggren J; Recipharm Pharmaceutical Development AB, Solna, Sweden.
Alderborn G; Department of Pharmacy, Uppsala University, Uppsala, Sweden.

Eur J Pharm Sci ; 114: 138-145, 2018 Mar 01.

Article in En | MEDLINE | ID: mdl-29217203

Subject(s)

Chemistry, Pharmaceutical/methods; Lactose/chemical synthesis; Particle Size; Plastics/chemical synthesis; Drug Compounding/methods; Powders; X-Ray Diffraction/methods

Key words

Amorphous lactose; Compression; Elasticity; Milling-induced disorder; Plasticity; Raman spectroscopy

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Particle Size / Plastics / Chemistry, Pharmaceutical / Lactose Language: En Journal: Eur J Pharm Sci Journal subject: FARMACIA / FARMACOLOGIA / QUIMICA Year: 2018 Document type: Article Country of publication: Netherlands

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