Four new compounds from the roots of Euphorbia ebracteolata and their inhibitory effect on LPS-induced NO production.
Fitoterapia
; 125: 235-239, 2018 Mar.
Article
in En
| MEDLINE
| ID: mdl-29221703
ABSTRACT
Three new diterpenoids, ebractenoids O~Q (1-3), and a new phenolic glucoside, γ-pyrone-3-O-ß-d-(6-galloyl)-glucopyranoside (4), together with 6 known compounds, were isolated from the 95% ethanol extract of the roots of Euphorbia ebracteolata, and their structures were elucidated on the basis of spectroscopic data. The absolute configurations of 1-3 were determined by electronic circular dichroism (ECD) calculations. The inhibitory effects of all the isolates with exception of compounds 8 and 10 on the NO production in lipopolysaccharide (LPS)-induced macrophages were evaluated. All of them exhibited significant inhibitory activity.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenols
/
Euphorbia
/
Diterpenes
/
Glucosides
Limits:
Animals
Language:
En
Journal:
Fitoterapia
Year:
2018
Document type:
Article