Programming Morphogenesis through Systems and Synthetic Biology.
Trends Biotechnol
; 36(4): 415-429, 2018 04.
Article
in En
| MEDLINE
| ID: mdl-29229492
ABSTRACT
Mammalian tissue development is an intricate, spatiotemporal process of self-organization that emerges from gene regulatory networks of differentiating stem cells. A major goal in stem cell biology is to gain a sufficient understanding of gene regulatory networks and cell-cell interactions to enable the reliable and robust engineering of morphogenesis. Here, we review advances in synthetic biology, single cell genomics, and multiscale modeling, which, when synthesized, provide a framework to achieve the ambitious goal of programming morphogenesis in complex tissues and organoids.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Organoids
/
Pluripotent Stem Cells
/
Systems Biology
/
Morphogenesis
Limits:
Animals
/
Humans
Language:
En
Journal:
Trends Biotechnol
Year:
2018
Document type:
Article