G Protein-Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus.
Pharmacol Rev
; 70(1): 39-67, 2018 01.
Article
in En
| MEDLINE
| ID: mdl-29233848
ABSTRACT
G protein-coupled receptors (GPCRs) continue to be important discovery targets for the treatment of type 2 diabetes mellitus (T2DM). Many GPCRs are directly involved in the development of insulin resistance and ß-cell dysfunction, and in the etiology of inflammation that can lead to obesity-induced T2DM. This review summarizes the current literature describing a number of well-validated GPCR targets, but also outlines several new and promising targets for drug discovery. We highlight the importance of understanding the role of these receptors in the disease pathology, and their basic pharmacology, which will pave the way to the development of novel pharmacological probes that will enable these targets to fulfill their promise for the treatment of these metabolic disorders.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Insulin Resistance
/
Receptors, G-Protein-Coupled
/
Diabetes Mellitus, Type 2
/
Obesity
Limits:
Animals
/
Humans
Language:
En
Journal:
Pharmacol Rev
Year:
2018
Document type:
Article