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Nanoparticles of metal-organic cages designed to encapsulate platinum-based anticancer agents.
Yue, Zhizhou; Wang, Han; Bowers, David J; Gao, Min; Stilgenbauer, Morgan; Nielsen, Frederick; Shelley, Jacob T; Zheng, Yao-Rong.
Affiliation
  • Yue Z; Department of Chemistry and Biochemistry, Kent State University, 224 Williams Hall, Kent, Ohio 44242, USA. yzheng7@kent.edu.
Dalton Trans ; 47(3): 670-674, 2018 Jan 15.
Article in En | MEDLINE | ID: mdl-29257160
We present a novel design to use metal-organic cages (MOCs) to encapsulate Pt-based anticancer agents for delivery. A fluorescein-conjugated Pt(iv) prodrug of cisplatin is developed for its encapsulation in a cationic MOC via host-guest interactions, which then forms drug-loaded nanoparticles with an anionic polymer.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organometallic Compounds / Drug Carriers / Cisplatin / Nanoparticles / Antineoplastic Agents Limits: Humans Language: En Journal: Dalton Trans Journal subject: QUIMICA Year: 2018 Document type: Article Affiliation country: United States Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organometallic Compounds / Drug Carriers / Cisplatin / Nanoparticles / Antineoplastic Agents Limits: Humans Language: En Journal: Dalton Trans Journal subject: QUIMICA Year: 2018 Document type: Article Affiliation country: United States Country of publication: United kingdom