Impact of Urgent Chemotherapy in Critically Ill Patients.
J Intensive Care Med
; 35(4): 347-353, 2020 Apr.
Article
in En
| MEDLINE
| ID: mdl-29258386
ABSTRACT
OBJECTIVE:
Compare the mortality between critically ill patients who received urgent chemotherapy for a cancer-related life-threatening complication with matched patients (controls) who did not received it.DESIGN:
Propensity score-matched retrospective study.SETTING:
Adult intensive care unit in an oncological hospital.PARTICIPANTS:
All adults with solid tumor or hematological malignancies who received at least 1 day of urgent intravenous chemotherapy for a cancer-related life-threatening complication. Using the propensity score method adjusted for 10 variables, patients who received urgent chemotherapy were matched to patients who did not.INTERVENTIONS:
None. MAIN OUTCOMESMEASURES:
Intensive care unit and hospital mortality.RESULTS:
Forty-seven patients (57% with solid tumors and 43% with hematological malignancies) who received urgent chemotherapy were matched to 94 controls. At intensive care unit admission, patients were similar except that those who received urgent chemotherapy were less likely to have received chemotherapy previously (36% vs 85%; P < .01). The intensive care unit (48.9% vs 23.4%; P < .01) and hospital (76.6% vs 46.8%; P < .01) mortality of the patients who received urgent chemotherapy was higher than the controls. The subgroup analysis showed that the higher mortality was limited to patients with solid tumor.CONCLUSION:
The use of urgent chemotherapy is associated with an increase in the intensive care unit and hospital mortality of unselected critically ill patients with solid tumors but not in patients with hematological malignancies.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hospital Mortality
/
Hematologic Neoplasms
/
Intensive Care Units
/
Life Support Care
/
Neoplasms
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adult
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Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
J Intensive Care Med
Journal subject:
TERAPIA INTENSIVA
Year:
2020
Document type:
Article
Affiliation country:
Brazil
Country of publication:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
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US
/
USA