Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14&#945;-Demethylase.

Sagatova, Alia A; Keniya, Mikhail V; Tyndall, Joel D A; Monk, Brian C

Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14α-Demethylase.

Sagatova, Alia A; Keniya, Mikhail V; Tyndall, Joel D A; Monk, Brian C.

Affiliation

Sagatova AA; Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand alia.sagatova@otago.ac.nz.
Keniya MV; Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand.
Tyndall JDA; School of Pharmacy, University of Otago, Dunedin, New Zealand.
Monk BC; Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand.

Antimicrob Agents Chemother ; 62(3)2018 03.

Article in En | MEDLINE | ID: mdl-29263059

Subject(s)

Antifungal Agents/chemistry; Aspergillus fumigatus/genetics; Candida albicans/genetics; Drug Resistance, Fungal/genetics; Fungal Proteins/genetics; Saccharomyces cerevisiae/genetics; Sterol 14-Demethylase/genetics; Antifungal Agents/metabolism; Antifungal Agents/pharmacology; Aspergillus fumigatus/enzymology; Candida albicans/enzymology; Catalytic Domain; Cloning, Molecular; Crystallography, X-Ray; Fluconazole/chemistry; Fluconazole/metabolism; Fluconazole/pharmacology; Fungal Proteins/chemistry; Fungal Proteins/metabolism; Gene Expression; Genetic Vectors/chemistry; Genetic Vectors/metabolism; Histidine/genetics; Histidine/metabolism; Itraconazole/chemistry; Itraconazole/metabolism; Itraconazole/pharmacology; Kinetics; Microbial Sensitivity Tests; Models, Molecular; Mutation; Oligopeptides/genetics; Oligopeptides/metabolism; Protein Binding; Protein Conformation, alpha-Helical; Protein Interaction Domains and Motifs; Recombinant Fusion Proteins/chemistry; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Recombinant Proteins/chemistry; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Saccharomyces cerevisiae/drug effects; Saccharomyces cerevisiae/enzymology; Sterol 14-Demethylase/chemistry; Sterol 14-Demethylase/metabolism; Substrate Specificity

Key words

CYP51; X-ray crystallography; antifungal resistance; drug resistance mechanisms; fluconazole; fungal infections; itraconazole; lanosterol 14α-demethylase; voriconazole

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aspergillus fumigatus / Saccharomyces cerevisiae / Candida albicans / Fungal Proteins / Drug Resistance, Fungal / Sterol 14-Demethylase / Antifungal Agents Language: En Journal: Antimicrob Agents Chemother Year: 2018 Document type: Article Affiliation country: New Zealand Country of publication: United States

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