Myasthenia Gravis Complicated with Peripheral T-cell Lymphoma, Not Otherwise Specified (PTCL-NOS), Following Thymectomy and Longstanding Tacrolimus Therapy.
Intern Med
; 57(4): 601-604, 2018 Feb 15.
Article
in En
| MEDLINE
| ID: mdl-29269644
ABSTRACT
Myasthenia gravis (MG), a neuromuscular junction autoimmune disease, sometimes complicates second malignancies; however, T-cell lymphoproliferative disorders have rarely been reported. A 55-year-old man, who received oral tacrolimus and prednisolone for MG for 16 years after thymectomy, presented with left abdominal pain, lymphadenopathy, and splenomegaly. A lymph node biopsy revealed peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). This is the first report of oral tacrolimus leading to a T-cell lymphoproliferative disorder in patient without a history of transplantation. Physicians should be aware of the possibility of rare T-cell lymphoproliferative disorders, such as PTCL-NOS, occurring as complications in MG patients on immunosuppressive regimens after thymectomy.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thymectomy
/
Lymphoma, T-Cell, Peripheral
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Tacrolimus
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Immunosuppressive Agents
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Myasthenia Gravis
Limits:
Humans
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Male
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Middle aged
Language:
En
Journal:
Intern Med
Journal subject:
MEDICINA INTERNA
Year:
2018
Document type:
Article
Affiliation country:
Japan