Clinical impact of culture-positive preservation fluid on solid organ transplantation: A systematic review and meta-analysis.
Transplant Rev (Orlando)
; 32(2): 85-91, 2018 04.
Article
in En
| MEDLINE
| ID: mdl-29275111
ABSTRACT
Contamination of the preservation fluid (PF) used for donated organs is a potential source of post-transplant infection. However, the information on this issue is scarce. We therefore conducted a systematic review and meta-analysis to assess the incidence of culture-positive PF and its impact on solid organ transplant (SOT) recipients. Seventeen studies were identified and included. The overall incidence of culture-positive PF was 37% (95% CI 27% to 49%), and the incidence of PF-related infections among SOT recipients with PF cultures that grew pathogenic microorganisms was 10% (95% CI 7% to 15%). There were differences in the rates of infections due to pathogenic microorganisms between SOT recipients who received pre-emptive treatment and those who did not, but without statistical significance. The mortality rate among SOT recipients with PF-related infection was 35% (95% CI 21% to 53%). In conclusion, although contamination of the PF of donated organs is frequent, the incidence of PF-related infection is relatively low. A closely clinical and microbiologic monitoring of the SOT recipient in case of culture-positive PF, regardless of the type of microorganism isolated might be do in order to establish a prompt diagnosis of PF-related infection.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Postoperative Complications
/
Drug Contamination
/
Organ Transplantation
/
Organ Preservation Solutions
Type of study:
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Transplant Rev (Orlando)
Journal subject:
TRANSPLANTE
Year:
2018
Document type:
Article