Engineered Sialylation of Pathogenic Antibodies In Vivo Attenuates Autoimmune Disease.

Pagan, Jose D; Kitaoka, Maya; Anthony, Robert M

Engineered Sialylation of Pathogenic Antibodies In Vivo Attenuates Autoimmune Disease.

Pagan, Jose D; Kitaoka, Maya; Anthony, Robert M.

Affiliation

Pagan JD; Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
Kitaoka M; Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
Anthony RM; Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA. Electronic address: robert.anthony@mgh.harvard.edu.

Cell ; 172(3): 564-577.e13, 2018 01 25.

Article in En | MEDLINE | ID: mdl-29275858

Subject(s)

Autoimmune Diseases/immunology; Immunoglobulin G/metabolism; Immunotherapy/methods; Protein Processing, Post-Translational; Sialic Acids/metabolism; Animals; Autoimmune Diseases/therapy; Cells, Cultured; Female; Glycosylation; HEK293 Cells; Humans; Immunoglobulin G/immunology; Mice; Mice, Inbred C57BL; Sialyltransferases/genetics; Sialyltransferases/metabolism

Key words

Antibody; autoimmune disease therapy; glycosylation; inflammation; platelets; sialic acid

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sialic Acids / Autoimmune Diseases / Immunoglobulin G / Protein Processing, Post-Translational / Immunotherapy Limits: Animals / Female / Humans Language: En Journal: Cell Year: 2018 Document type: Article Affiliation country: United States Country of publication: United States

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