Separation of pathogenic bacteria by chain length.
Anal Chim Acta
; 1000: 223-231, 2018 Feb 13.
Article
in En
| MEDLINE
| ID: mdl-29289314
ABSTRACT
Using Deterministic Lateral Displacement devices optimized for sensitivity to particle length, we separate subpopulations of bacteria depending on known properties that affect their capability to cause disease (virulence). For the human bacterial pathogen Streptococcus pneumoniae, bacterial chain length and the presence of a capsule are known virulence factors contributing to its ability to cause severe disease. Separation of cultured pneumococci into subpopulations based on morphological type (single cocci, diplococci and chains) will enable more detailed studies of the role they play in virulence. Moreover, we present separation of mixed populations of almost genetically identical encapsulated and non-encapsulated pneumococcal strains in our device.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Streptococcus pneumoniae
/
Microfluidic Analytical Techniques
Language:
En
Journal:
Anal Chim Acta
Year:
2018
Document type:
Article
Affiliation country:
Sweden