BODIPYs to the rescue: Potential applications in photodynamic inactivation.
Eur J Med Chem
; 144: 651-661, 2018 Jan 20.
Article
in En
| MEDLINE
| ID: mdl-29289888
ABSTRACT
4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) derivatives have been proposed in several potential biomedical applications. BODIPYs absorb strongly in blue-green region with high fluorescence emission, properties that convert them in effective fluorophores in the field of biological labeling. However, BODIPY structures can be conveniently modified by heavy atoms substitution to obtain photosensitizers with applications in photodynamic therapy. Also, external heavy atoms effect can be used to increase the photodynamic activity of these compounds. In recent years, BODIPYs have been proposed as phototherapeutic agents for the photodynamic inactivation of microorganisms. Therefore, BODIPY structures need to be optimized to produce an efficient photocytotoxic activity. In this way, amphiphilic cationic BODIPYs can selectively bind to microbial cells, inducing an effective photokilling of pathogenic microbial cells. This review summarizes the attributes of BODIPY derivatives for applications as antimicrobial photosensitizing agents.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Photochemotherapy
/
Boron Compounds
/
Photosensitizing Agents
/
Fluorescent Dyes
Limits:
Humans
Language:
En
Journal:
Eur J Med Chem
Year:
2018
Document type:
Article
Affiliation country:
Argentina