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Effects of multiple sclerosis and medications on menopausal age.
Türk Börü, Ülkü; Köseoglu Toksoy, Cansu; Bölük, Cem; Bilgiç, Adnan; Tasdemir, Mustafa.
Affiliation
  • Türk Börü Ü; 1 University of Health Sciences Dr. Lütfi Kirdar Kartal Training and Research Hospital, Department of Neurology, Istanbul, Turkey.
  • Köseoglu Toksoy C; 1 University of Health Sciences Dr. Lütfi Kirdar Kartal Training and Research Hospital, Department of Neurology, Istanbul, Turkey.
  • Bölük C; 1 University of Health Sciences Dr. Lütfi Kirdar Kartal Training and Research Hospital, Department of Neurology, Istanbul, Turkey.
  • Bilgiç A; 2 Konya Eregli State Hospital, Department of Neurology, Konya, Turkey.
  • Tasdemir M; 3 Istanbul Medeniyet University, Department of Public Health, Istanbul, Turkey.
J Int Med Res ; 46(3): 1249-1253, 2018 Mar.
Article in En | MEDLINE | ID: mdl-29332426
Objectives We aimed to determine whether multiple sclerosis (MS) and methylprednisolone and disease-modifying drugs have an effect on menopausal age. Methods A total of 86 patients and 98 healthy subjects were included in this study. The natural menopausal age of the patients and healthy subjects were compared. The cumulative dosages of methylprednisolone, beta interferons (IFNßs), and glatiramer acetate were calculated. The effects of the Expanded Disability Status Scale (EDSS), duration of the disease, and cumulative dosage of medications on menopausal age were evaluated. Results The patients' mean menopausal age was 45.3 ± 4.8 years and healthy subjects' menopausal age was 46.8 ± 4.3 years, with no significant difference between the two groups. The cumulative dosage of methylprednisolone showed an effect on menopausal age. There was a significant inverse correlation between menopausal age and dosage of IFNß-1b, while the disease duration and EDSS score showed no correlation with menopausal age. Conclusions We conclude that menopausal age is not affected by MS. However, long-term methylprednisolone and IFNß-1b treatments may change menopausal age in a dose-dependent manner.
Subject(s)
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Menopause / Methylprednisolone / Interferon-beta / Glatiramer Acetate / Immunosuppressive Agents / Multiple Sclerosis Type of study: Observational_studies Limits: Adult / Female / Humans / Middle aged Language: En Journal: J Int Med Res Year: 2018 Document type: Article Affiliation country: Turkey Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Menopause / Methylprednisolone / Interferon-beta / Glatiramer Acetate / Immunosuppressive Agents / Multiple Sclerosis Type of study: Observational_studies Limits: Adult / Female / Humans / Middle aged Language: En Journal: J Int Med Res Year: 2018 Document type: Article Affiliation country: Turkey Country of publication: United kingdom