[Role of programmed death-1 in viral infectious diseases].
Zhongguo Dang Dai Er Ke Za Zhi
; 20(1): 77-82, 2018 Jan.
Article
in Zh
| MEDLINE
| ID: mdl-29335088
ABSTRACT
The research on the immunoregulatory effect of programmed death-1 (PD-1) in infectious diseases mainly focuses on chronic viral infection, but there are few studies on acute viral infection. In chronic viral infection, PD-1 is highly expressed on the surface of CD8+ T cells, which is a sign of CD8+ T cell depletion. Recent studies have shown that in chronic viral infection, PD-1 is also highly expressed on the surface of regulatory T cells and binds to programmed death-ligand 1 (PD-L1) on the surface of exhausted CD8+ T cells, resulting in a stronger inhibitory effect on CD8+ T cell immunity. Blocking the PD-1/PD-L1 signaling pathway between exhausted CD8+ T cells and regulatory T cells can significantly reverse the depletion of CD8+ T cells and greatly improve the antiviral effect of CD8+ T cells. However, the role of the PD-1/PD-L1 signaling pathway in acute viral infection remains unknown. This article summarizes the latest research on PD-1 in infectious diseases and discusses its role in acute and chronic viral infection.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Virus Diseases
/
Programmed Cell Death 1 Receptor
Limits:
Humans
Language:
Zh
Journal:
Zhongguo Dang Dai Er Ke Za Zhi
Year:
2018
Document type:
Article
Affiliation country:
China