Pregabalin versus placebo in targeting pro-nociceptive mechanisms to prevent chronic pain after whiplash injury in at-risk individuals - a feasibility study for a randomised controlled trial.

Nikles, J; Keijzers, G; Mitchell, G; Schug, S; Ware, R; McLean, S A; Connelly, L; Gibson, S; Farrell, S F; Sterling, M

Nikles, J; Keijzers, G; Mitchell, G; Schug, S; Ware, R; McLean, S A; Connelly, L; Gibson, S; Farrell, S F; Sterling, M.

Affiliation

Nikles J; Recover Injury Research Centre, NHMRC Centre of Research Excellence in Recovery Following Road Traffic Injuries, The University of Queensland, Herston, Australia.
Keijzers G; Department of Emergency Medicine, Gold Coast Hospital and Health Service, Gold Coast, Queensland, Australia.
Mitchell G; School of Medicine, Bond University, Gold Coast, QLD, Australia.
Schug S; School of Medicine, Griffith University, Gold Coast, QLD, Australia.
Ware R; Faculty of Medicine, The University of Queensland, Herston, Australia.
McLean SA; School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia.
Connelly L; Menzies Health Institute Queensland, Griffith University, Brisbane, Australia.
Gibson S; Institute for Trauma Recovery, Department of Anesthesiology, University of North Carolina School of Medicine, Chapel Hill, USA.
Farrell SF; Recover Injury Research Centre, NHMRC Centre of Research Excellence in Recovery Following Road Traffic Injuries, The University of Queensland, Herston, Australia.
Sterling M; Centre for the Business and Economics of Health, University of Queensland, Brisbane, Australia.

Trials ; 19(1): 44, 2018 Jan 17.

Article in En | MEDLINE | ID: mdl-29343280

Subject(s)

Analgesics/therapeutic use; Chronic Pain/prevention & control; Neck Pain/prevention & control; Nociceptive Pain/prevention & control; Pregabalin/therapeutic use; Whiplash Injuries/drug therapy; Adolescent; Adult; Aged; Analgesics/adverse effects; Chronic Pain/diagnosis; Chronic Pain/physiopathology; Chronic Pain/psychology; Double-Blind Method; Feasibility Studies; Female; Humans; Male; Middle Aged; Multicenter Studies as Topic; Neck Pain/diagnosis; Neck Pain/physiopathology; Neck Pain/psychology; Nociceptive Pain/diagnosis; Nociceptive Pain/physiopathology; Nociceptive Pain/psychology; Pain Measurement; Pregabalin/adverse effects; Queensland; Randomized Controlled Trials as Topic; Time Factors; Treatment Outcome; Whiplash Injuries/diagnosis; Whiplash Injuries/physiopathology; Whiplash Injuries/psychology; Young Adult

Key words

Feasibility study; Motor vehicle crash; Pregabalin; Randomised controlled trial; Whiplash-associated disorders

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Whiplash Injuries / Neck Pain / Chronic Pain / Nociceptive Pain / Pregabalin / Analgesics Type of study: Clinical_trials / Diagnostic_studies / Etiology_studies / Guideline / Risk_factors_studies Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Oceania Language: En Journal: Trials Journal subject: MEDICINA / TERAPEUTICA Year: 2018 Document type: Article Affiliation country: Australia Country of publication: United kingdom

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