Your browser doesn't support javascript.
loading
Efficacy of One-Year Treatment with Aflibercept for Diabetic Macular Edema with Practical Protocol.
Kaiho, Tomomi; Oshitari, Toshiyuki; Tatsumi, Tomoaki; Takatsuna, Yoko; Arai, Miyuki; Shimizu, Norihiro; Sato, Eiju; Baba, Takayuki; Yamamoto, Shuichi.
Affiliation
  • Kaiho T; Department of Ophthalmology and Visual Science, Chiba University, Graduate School of Medicine, Chiba, Japan.
  • Oshitari T; Department of Ophthalmology and Visual Science, Chiba University, Graduate School of Medicine, Chiba, Japan.
  • Tatsumi T; Department of Ophthalmology and Visual Science, Chiba University, Graduate School of Medicine, Chiba, Japan.
  • Takatsuna Y; Department of Ophthalmology and Visual Science, Chiba University, Graduate School of Medicine, Chiba, Japan.
  • Arai M; Department of Ophthalmology and Visual Science, Chiba University, Graduate School of Medicine, Chiba, Japan.
  • Shimizu N; Department of Ophthalmology and Visual Science, Chiba University, Graduate School of Medicine, Chiba, Japan.
  • Sato E; Department of Ophthalmology and Visual Science, Chiba University, Graduate School of Medicine, Chiba, Japan.
  • Baba T; Department of Ophthalmology and Visual Science, Chiba University, Graduate School of Medicine, Chiba, Japan.
  • Yamamoto S; Department of Ophthalmology and Visual Science, Chiba University, Graduate School of Medicine, Chiba, Japan.
Biomed Res Int ; 2017: 7879691, 2017.
Article in En | MEDLINE | ID: mdl-29349082
ABSTRACT
The purpose of this study was to determine the efficacy of one-year treatment of diabetic macular edema (DME) with intravitreal aflibercept (IVA) injections on a practical protocol. The medical records of 51 eyes of 43 patients who were diagnosed with DME and had received IVA treatments were reviewed. The best-corrected visual acuity (BCVA) and the central macular thickness (CMT) were measured at the baseline and at 1, 3, 6, and 12 months after the IVA. The mean number of IVA injections was 3.8 ± 2.4. The mean BCVA was significantly better and the CMT was thinner after the IVA at all follow-up times (P < 0.05). The BCVA was better in eyes with a serous retinal detachment (SRD) than without a SRD (P < 0.01). There was a significant correlation between the photoreceptor outer segment (PROS) length and BCVA at the baseline and at 12 months after the IVA (P < 0.05). A fewer number of IVA injections significantly improved the BCVA and the CMT in eyes with DME after one-year treatment. IVA was more effective in the SRD+ group than in the SRD- group. The PROS length may be a predictive marker for visual outcomes after one-year treatment with IVA for DME (IRB#2272).
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Fusion Proteins / Macular Edema / Angiogenesis Inhibitors / Receptors, Vascular Endothelial Growth Factor / Diabetic Retinopathy Type of study: Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Biomed Res Int Year: 2017 Document type: Article Affiliation country: Japan

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Fusion Proteins / Macular Edema / Angiogenesis Inhibitors / Receptors, Vascular Endothelial Growth Factor / Diabetic Retinopathy Type of study: Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Biomed Res Int Year: 2017 Document type: Article Affiliation country: Japan