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Targeting PERK signaling with the small molecule GSK2606414 prevents neurodegeneration in a model of Parkinson's disease.
Mercado, Gabriela; Castillo, Valentina; Soto, Paulina; López, Nélida; Axten, Jeffrey M; Sardi, Sergio P; Hoozemans, Jeroen J M; Hetz, Claudio.
Affiliation
  • Mercado G; Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile. Electronic address: m
  • Castillo V; Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.
  • Soto P; Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.
  • López N; Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.
  • Axten JM; Virtual Proof of Concept Discovery Performance Unit, GlaxoSmithKline, PA, USA.
  • Sardi SP; Neuroscience Therapeutic Area, Sanofi, 49 New York Avenue, Framingham, MA 01701, USA.
  • Hoozemans JJM; Department of Pathology, VU University Medical Center, Amsterdam Neuroscience, Amsterdam, The Netherlands.
  • Hetz C; Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile; Buck Institute for Re
Neurobiol Dis ; 112: 136-148, 2018 04.
Article in En | MEDLINE | ID: mdl-29355603
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adenine / Signal Transduction / EIF-2 Kinase / Parkinsonian Disorders / Disease Models, Animal / Indoles Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2018 Document type: Article Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adenine / Signal Transduction / EIF-2 Kinase / Parkinsonian Disorders / Disease Models, Animal / Indoles Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2018 Document type: Article Country of publication: United States