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Testicular MTHFR deficiency may explain sperm DNA hypomethylation associated with high dose folic acid supplementation.
Aarabi, Mahmoud; Christensen, Karen E; Chan, Donovan; Leclerc, Daniel; Landry, Mylène; Ly, Lundi; Rozen, Rima; Trasler, Jacquetta.
Affiliation
  • Aarabi M; Department of Human Genetics, McGill University, Montreal, QC H4A 3J1, Canada.
  • Christensen KE; Child Health and Human Development Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.
  • Chan D; Child Health and Human Development Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.
  • Leclerc D; Child Health and Human Development Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.
  • Landry M; Child Health and Human Development Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.
  • Ly L; Child Health and Human Development Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.
  • Rozen R; Department of Human Genetics, McGill University, Montreal, QC H4A 3J1, Canada.
  • Trasler J; Child Health and Human Development Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.
Hum Mol Genet ; 27(7): 1123-1135, 2018 04 01.
Article in En | MEDLINE | ID: mdl-29360980
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spermatozoa / Testis / DNA / DNA Methylation / Methylenetetrahydrofolate Reductase (NADPH2) / Folic Acid Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2018 Document type: Article Affiliation country: Canada
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spermatozoa / Testis / DNA / DNA Methylation / Methylenetetrahydrofolate Reductase (NADPH2) / Folic Acid Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2018 Document type: Article Affiliation country: Canada