[Idiopathic hypercalciuria. Diagnosis and treatment].
Urologiia
; (6): 112-119, 2017 Dec.
Article
in Ru
| MEDLINE
| ID: mdl-29376607
ABSTRACT
Most patients with idiopathic hypercalciuria and calcium nephrolithiasis have a family history of the disease. Idiopathic hypercalciuria is a metabolic abnormality with various causes and developmental pathways. The systematic review describes specific mutations associated with idiopathic hypercalciuria and nephrolithiasis. Detection of these mutations may provide a better understanding of the pathogenesis of this heterogeneous disease and personalize patient management depending on the detected polymorphisms. A promising treatment option for a mutation in the vitamin D receptor gene is thiazide diuretics in combination with bisphosphonates. Among bisphosphonates, the drug of choice which has been most strongly supported by research evidence is alendronate.
Key words
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, Calcitriol
/
Alendronate
/
Nephrolithiasis
/
Mutation
Type of study:
Diagnostic_studies
/
Systematic_reviews
Limits:
Female
/
Humans
/
Male
Language:
Ru
Journal:
Urologiia
Journal subject:
UROLOGIA
Year:
2017
Document type:
Article
Affiliation country:
RUSSIA