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Facile Synthesis, Geometry, and 2'-Substituent-Dependent in Vivo Activity of 5'-(E)- and 5'-(Z)-Vinylphosphonate-Modified siRNA Conjugates.
Parmar, Rubina Giare; Brown, Christopher R; Matsuda, Shigeo; Willoughby, Jennifer L S; Theile, Christopher S; Charissé, Klaus; Foster, Donald J; Zlatev, Ivan; Jadhav, Vasant; Maier, Martin A; Egli, Martin; Manoharan, Muthiah; Rajeev, Kallanthottathil G.
Affiliation
  • Parmar RG; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Brown CR; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Matsuda S; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Willoughby JLS; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Theile CS; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Charissé K; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Foster DJ; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Zlatev I; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Jadhav V; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Maier MA; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Egli M; Department of Biochemistry and Center for Structural Biology, Vanderbilt University, School of Medicine , Nashville, Tennessee 37232, United States.
  • Manoharan M; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Rajeev KG; Alnylam Pharmaceuticals , 300 Third Street, Cambridge, Massachusetts 02142, United States.
J Med Chem ; 61(3): 734-744, 2018 02 08.
Article in En | MEDLINE | ID: mdl-29376650
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Small Interfering / Organophosphonates Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2018 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Small Interfering / Organophosphonates Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2018 Document type: Article Affiliation country: United States