Towards multi-phase postmortem CT angiography in children: a study on a porcine model.
Int J Legal Med
; 132(5): 1391-1403, 2018 Sep.
Article
in En
| MEDLINE
| ID: mdl-29380125
ABSTRACT
PURPOSE:
Multi-phase postmortem computed tomography angiography (MPMCTA) is a growing technique, which is standardized for adults. Application of this protocol for a children population is not so well defined. Our study aims to adapt the adult's protocol to children, using a porcine model. MATERIAL ANDMETHODS:
Three groups of 18 pigs were studied, with a weight distribution between 4 and 48 kg. Different pump devices were used. Pigs of group I were studied using the Virtangio® machine, whereas pigs of groups II and III were studied using used the Medrad® machine. Study of vascular opacification was possible using a semi-quantitative method based on 26 arterial and 26 venous segments that were distributed over the entire body from the cephalic extremity to the posterior pawns.RESULTS:
While thoracic, abdominal, and pelvic vascular opacification were complete for each individual pig in a group, group III showed better vascular opacification for the cephalic extremity. This was also true for anterior and posterior pawns vascular opacification. Spearman correlation tests showed a significant relationship between anthropometric characteristics of pigs, injection parameters, and percentage of opacified segments. A higher percentage of opacification was obtained for individuals of lower weights, with comparatively lower quantities of contrast agent injected.CONCLUSION:
Postmortem computed tomography angiography (PMCTA) was possible for all the individuals, particularly for small weights (4 kg) using the Medrad® machine. However, further studies are needed to better understand the procedure.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Autopsy
/
Disease Models, Animal
/
Computed Tomography Angiography
Type of study:
Prognostic_studies
Limits:
Animals
/
Child
/
Humans
Language:
En
Journal:
Int J Legal Med
Journal subject:
JURISPRUDENCIA
Year:
2018
Document type:
Article
Affiliation country:
France