Bone Marrow Micro-Environment in Normal and Deranged Hematopoiesis: Opportunities for Regenerative Medicine and Therapies.

Sarkaria, Shawn M; Decker, Matthew; Ding, Lei

Sarkaria, Shawn M; Decker, Matthew; Ding, Lei.

Affiliation

Sarkaria SM; Department of Rehabilitation and Regenerative Medicine, Department of Microbiology and Immunology, Columbia Stem Cell Initiative, Columbia University Medical Center, 630 West 168th ST, P&S 7-513, New York, 10032, New York, USA.
Decker M; Department of Rehabilitation and Regenerative Medicine, Department of Microbiology and Immunology, Columbia Stem Cell Initiative, Columbia University Medical Center, 630 West 168th ST, P&S 7-513, New York, 10032, New York, USA.
Ding L; Department of Rehabilitation and Regenerative Medicine, Department of Microbiology and Immunology, Columbia Stem Cell Initiative, Columbia University Medical Center, 630 West 168th ST, P&S 7-513, New York, 10032, New York, USA.

Bioessays ; 40(3)2018 03.

Article in En | MEDLINE | ID: mdl-29384206

Subject(s)

Gene Expression Regulation, Neoplastic; Hematologic Neoplasms/drug therapy; Hematopoiesis/drug effects; Neoplastic Stem Cells/drug effects; Stem Cell Niche/drug effects; Tumor Microenvironment/drug effects; Animals; Antineoplastic Agents/therapeutic use; Bone Marrow/drug effects; Bone Marrow/metabolism; Bone Marrow/pathology; Bone Marrow Cells/drug effects; Bone Marrow Cells/metabolism; Bone Marrow Cells/pathology; Hematologic Neoplasms/genetics; Hematologic Neoplasms/metabolism; Hematologic Neoplasms/pathology; Hematopoiesis/genetics; Hematopoietic Stem Cells/drug effects; Hematopoietic Stem Cells/metabolism; Hematopoietic Stem Cells/pathology; Humans; Molecular Targeted Therapy/methods; Neoplasm Proteins/antagonists & inhibitors; Neoplasm Proteins/genetics; Neoplasm Proteins/metabolism; Neoplasm, Residual; Neoplastic Stem Cells/metabolism; Neoplastic Stem Cells/pathology; Regenerative Medicine/methods; Stem Cell Niche/genetics; Tumor Microenvironment/genetics

Key words

HSC; cross-talk; hematological diseases; hematopoiesis; niche; premalignant; treatment

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplastic Stem Cells / Gene Expression Regulation, Neoplastic / Hematologic Neoplasms / Stem Cell Niche / Tumor Microenvironment / Hematopoiesis Limits: Animals / Humans Language: En Journal: Bioessays Journal subject: BIOLOGIA / BIOLOGIA MOLECULAR Year: 2018 Document type: Article Affiliation country: United States

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