Simulated microgravity hampers Notch signaling in the fight against myocardial ischemiareperfusion injury.
Mol Med Rep
; 17(4): 5150-5158, 2018 04.
Article
in En
| MEDLINE
| ID: mdl-29393447
ABSTRACT
The gravitational ï¬eld is an important determinant of cardiovascular function. Exposure to microgravity during spaceflight may lead to a series of maladaptive alterations in the cardiovascular system. The authors have previously demonstrated that microgravity can increase the susceptibility to myocardial ischemiareperfusion (IR) injury under simulated microgravity. Although Notch1 signaling protects against myocardial IR injury, whether Notch1 protects against myocardial IR injury under simulated weightlessness remains unknown. The present study is designed to investigate the role of the Notch1 receptor in myocardial IR injury under simulated weightlessness. The differences in Notch signaling expression and myocardial infarct size following myocardial IR were compared between normal rats and tailsuspended rats that were kept in 30Ë headdown tilt and hindlimb unloading position. The data revealed low expression levels of Notch1 receptor and its endogenous ligand Jagged1 in normal adult rat hearts. However, significantly higher expression of Notch1 was observed in the border zone compared with the infarcted area and the remote zone following myocardial IR. Notch1 expression was notably reduced in the infarcted hearts of tailsuspended rats compared with the control group. Conversely, the myocardial infarct size was significantly increased in tailsuspended rats compared with the control rats. In conclusion, these data suggested that the proper function of Notch signaling may be hampered under simulated microgravity.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Weightlessness
/
Myocardial Reperfusion Injury
/
Signal Transduction
/
Weightlessness Simulation
/
Receptors, Notch
Limits:
Animals
Language:
En
Journal:
Mol Med Rep
Year:
2018
Document type:
Article