Infant Iron Deficiency and Iron Supplementation Predict Adolescent Internalizing, Externalizing, and Social Problems.
J Pediatr
; 195: 199-205.e2, 2018 04.
Article
in En
| MEDLINE
| ID: mdl-29395182
ABSTRACT
OBJECTIVE:
To evaluate associations between iron supplementation and iron deficiency in infancy and internalizing, externalizing, and social problems in adolescence. STUDYDESIGN:
The study is a follow-up of infants as adolescents from working-class communities around Santiago, Chile who participated in a preventive trial of iron supplementation at 6 months of age. Inclusionary criteria included birth weight ≥3.0 kg, healthy singleton term birth, vaginal delivery, and a stable caregiver. Iron status was assessed at 12 and 18 months of age. At 11-17 years of age, internalizing, externalizing, and social problems were reported by 1018 adolescents with the Youth Self Report and by parents with the Child Behavior Checklist.RESULTS:
Adolescents who received iron supplementation in infancy had greater self-reported attention-deficit/hyperactivity disorder but lower parent-reported conduct disorder symptoms than those who did not (Ps < .05). Iron deficiency with or without anemia at 12 or 18 months of age predicted greater adolescent behavior problems compared with iron sufficiency more adolescent-reported anxiety and social problems, and parent-reported social, post-traumatic stress disorder, attention-deficit/hyperactivity disorder, oppositional defiant, conduct, aggression, and rule breaking problems (Ps < .05). The threshold was iron deficiency with or without anemia for each of these outcomes.CONCLUSIONS:
Iron deficiency with or without anemia in infancy was associated with increased internalizing, externalizing, and social problems in adolescence.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Anxiety
/
Attention Deficit Disorder with Hyperactivity
/
Trace Elements
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Anemia, Iron-Deficiency
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Conduct Disorder
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Dietary Supplements
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Iron
Type of study:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
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Risk_factors_studies
Limits:
Adolescent
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Child
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Female
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Humans
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Infant
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Male
Language:
En
Journal:
J Pediatr
Year:
2018
Document type:
Article