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Recent Advances in Nanoparticle-Based Cancer Drug and Gene Delivery.
Amreddy, Narsireddy; Babu, Anish; Muralidharan, Ranganayaki; Panneerselvam, Janani; Srivastava, Akhil; Ahmed, Rebaz; Mehta, Meghna; Munshi, Anupama; Ramesh, Rajagopal.
Affiliation
  • Amreddy N; The University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States; Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
  • Babu A; The University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States; Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
  • Muralidharan R; The University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States; Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
  • Panneerselvam J; The University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States; Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
  • Srivastava A; The University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States; Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
  • Ahmed R; The University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States; Graduate Program in Biomedical Sciences, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
  • Mehta M; The University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States; Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
  • Munshi A; The University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States; Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
  • Ramesh R; The University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States; Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States; Graduate Program in Biomedical Sciences, The University of Oklahoma Health Sciences Center, Oklahoma Cit
Adv Cancer Res ; 137: 115-170, 2018.
Article in En | MEDLINE | ID: mdl-29405974
ABSTRACT
Effective and safe delivery of anticancer agents is among the major challenges in cancer therapy. The majority of anticancer agents are toxic to normal cells, have poor bioavailability, and lack in vivo stability. Recent advancements in nanotechnology provide safe and efficient drug delivery systems for successful delivery of anticancer agents via nanoparticles. The physicochemical and functional properties of the nanoparticle vary for each of these anticancer agents, including chemotherapeutics, nucleic acid-based therapeutics, small molecule inhibitors, and photodynamic agents. The characteristics of the anticancer agents influence the design and development of nanoparticle carriers. This review focuses on strategies of nanoparticle-based drug delivery for various anticancer agents. Recent advancements in the field are also highlighted, with suitable examples from our own research efforts and from the literature.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Carriers / Drug Delivery Systems / Nanoparticles / Neoplasms / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Adv Cancer Res Year: 2018 Document type: Article Affiliation country: United States
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Carriers / Drug Delivery Systems / Nanoparticles / Neoplasms / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Adv Cancer Res Year: 2018 Document type: Article Affiliation country: United States