Complete elimination of a pathogenic homoplasmic mtDNA mutation in one generation.

Brady, Lauren; Sadikovic, Bekim; Rupar, C Anthony; Tarnopolsky, Mark A

Brady, Lauren; Sadikovic, Bekim; Rupar, C Anthony; Tarnopolsky, Mark A.

Affiliation

Brady L; Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.
Sadikovic B; Molecular Genetics Laboratory, Molecular Diagnostics Division, London Health Sciences Centre, Children's Health Research Institute, London, Ontario, Canada; Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada; Department of Pediatrics, Western University, Lon
Rupar CA; Molecular Genetics Laboratory, Molecular Diagnostics Division, London Health Sciences Centre, Children's Health Research Institute, London, Ontario, Canada; Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada; Department of Pediatrics, Western University, Lon
Tarnopolsky MA; Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. Electronic address: tarnopol@mcmaster.ca.

Mitochondrion ; 45: 18-21, 2019 03.

Article in En | MEDLINE | ID: mdl-29408632

Subject(s)

Ataxia/genetics; DNA, Mitochondrial/genetics; Dystonia/genetics; Infectious Disease Transmission, Vertical; Mitochondrial Diseases/genetics; Muscle Spasticity/genetics; Point Mutation; Female; Fibroblasts/pathology; Humans; Middle Aged; Muscles/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ataxia / DNA, Mitochondrial / Point Mutation / Infectious Disease Transmission, Vertical / Mitochondrial Diseases / Dystonia / Muscle Spasticity Type of study: Prognostic_studies Limits: Female / Humans / Middle aged Language: En Journal: Mitochondrion Year: 2019 Document type: Article Affiliation country: Canada Country of publication: Netherlands

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