The potential long-term neurological improvement of early hyperbaric oxygen therapy on hemorrhagic stroke in the diabetics.
Diabetes Res Clin Pract
; 138: 75-80, 2018 Apr.
Article
in En
| MEDLINE
| ID: mdl-29408705
ABSTRACT
AIMS:
Although Hyperbaric oxygen therapy (HyperBOT) attract our attention successfully these days, it is still full of controversy on the treatment of acute stroke. The aim of this study is to assess the potential long-term neurological consequences and safety of using HyperBOT on intracerebral hemorrhage (ICH) in the diabetics.METHODS:
In this prospective, randomized controlled trial, 79 diabetes patients suffering from acute ICH were randomized to treat for 60â¯min in a monoplace hyperbaric chamber pressurized with pure oxygen to 2.5-atm absolute (ATA) in the HyperBOT group or 1.5 ATA in the normobaric oxygen therapy (NormBOT) group, which was performed as control. Both short-term and long-term neurological consequences were studied and compared in each group on National Institutes of Health Stroke Scale [NIHSS], Barthel Index, modified Rankin Scale [mRS] and Glasgow Outcome Scale [GOS]. The related complications or side-events of all patients were recorded as well at the final follow-up of six months after onset.RESULTS:
No distinct difference was observed between each group at one month follow-up. However, in the long-term follow-up of six months, a higher frequency of patients in the HyperBOT group resulted into good outcome with a relative high neurological consequence compared with the NormBOT group (Barthel Index 85.1% versus 65.6%, Pâ¯=â¯0.080; mRS 89.4% versus 68.8%, Pâ¯=â¯0.045; GOS 83.0% versus 62.5%, Pâ¯=â¯0.073; NIHSS 80.9% versus 56.2%, Pâ¯=â¯0.035).CONCLUSIONS:
Early HyperBOT was found to be safe and effective with regards to the long-term neurological outcome of diabetic patients suffering from ICH.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cerebral Hemorrhage
/
Stroke
/
Diabetes Complications
/
Hyperbaric Oxygenation
Type of study:
Clinical_trials
/
Observational_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Diabetes Res Clin Pract
Journal subject:
ENDOCRINOLOGIA
Year:
2018
Document type:
Article
Publication country:
IE
/
IRELAND
/
IRLANDA