A new low-nephron CKD model with hypertension, progressive decline of renal function, and enhanced inflammation in C57BL/6 mice.

Wei, Jin; Zhang, Jie; Wang, Lei; Cha, Byeong Jake; Jiang, Shan; Liu, Ruisheng

Wei, Jin; Zhang, Jie; Wang, Lei; Cha, Byeong Jake; Jiang, Shan; Liu, Ruisheng.

Affiliation

Wei J; Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine , Tampa, Florida.
Zhang J; Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine , Tampa, Florida.
Wang L; Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine , Tampa, Florida.
Cha BJ; Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine , Tampa, Florida.
Jiang S; Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine , Tampa, Florida.
Liu R; Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine , Tampa, Florida.

Am J Physiol Renal Physiol ; 314(5): F1008-F1019, 2018 05 01.

Article in En | MEDLINE | ID: mdl-29412703

Subject(s)

Arterial Pressure; Glomerular Filtration Rate; Hypertension, Renovascular/physiopathology; Inflammation/physiopathology; Kidney/blood supply; Kidney/physiopathology; Renal Insufficiency, Chronic/physiopathology; Albuminuria/etiology; Albuminuria/physiopathology; Albuminuria/urine; Animals; Biomarkers/blood; Biomarkers/urine; Creatinine/blood; Disease Models, Animal; Disease Progression; Hypertension, Renovascular/blood; Hypertension, Renovascular/etiology; Hypertension, Renovascular/pathology; Inflammation/blood; Inflammation/etiology; Inflammation/pathology; Inflammation Mediators/blood; Kidney/ultrastructure; Ligation; Mice, Inbred C57BL; Nephrectomy; Renal Artery/physiopathology; Renal Artery/surgery; Renal Insufficiency, Chronic/blood; Renal Insufficiency, Chronic/etiology; Renal Insufficiency, Chronic/pathology; Renin/blood; Time Factors; Tumor Necrosis Factor-alpha/blood

Key words

chronic kidney disease

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Renal Insufficiency, Chronic / Arterial Pressure / Glomerular Filtration Rate / Hypertension, Renovascular / Inflammation / Kidney Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: Am J Physiol Renal Physiol Journal subject: FISIOLOGIA / NEFROLOGIA Year: 2018 Document type: Article

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