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Structure and biophysical characterization of the human full-length neurturin-GFRa2 complex: A role for heparan sulfate in signaling.
Sandmark, Jenny; Dahl, Göran; Öster, Linda; Xu, Bingze; Johansson, Patrik; Akerud, Tomas; Aagaard, Anna; Davidsson, Pia; Bigalke, Janna M; Winzell, Maria Sörhede; Rainey, G Jonah; Roth, Robert G.
Affiliation
  • Sandmark J; From the Departments of Structure, Biophysics and Fragment-based Lead Generation, Discovery Sciences.
  • Dahl G; From the Departments of Structure, Biophysics and Fragment-based Lead Generation, Discovery Sciences.
  • Öster L; From the Departments of Structure, Biophysics and Fragment-based Lead Generation, Discovery Sciences.
  • Xu B; the Division of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 17177, Sweden.
  • Johansson P; Discovery Biology, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg 43183, Sweden.
  • Akerud T; From the Departments of Structure, Biophysics and Fragment-based Lead Generation, Discovery Sciences.
  • Aagaard A; From the Departments of Structure, Biophysics and Fragment-based Lead Generation, Discovery Sciences.
  • Davidsson P; From the Departments of Structure, Biophysics and Fragment-based Lead Generation, Discovery Sciences.
  • Bigalke JM; Bioscience, Cardiovascular and Metabolic Diseases, and.
  • Winzell MS; From the Departments of Structure, Biophysics and Fragment-based Lead Generation, Discovery Sciences.
  • Rainey GJ; Bioscience, Cardiovascular and Metabolic Diseases, and.
  • Roth RG; the Department of Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, Maryland 20878, and.
J Biol Chem ; 293(15): 5492-5508, 2018 04 13.
Article in En | MEDLINE | ID: mdl-29414779
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Multiprotein Complexes / Neurturin / Glial Cell Line-Derived Neurotrophic Factor Receptors / Heparitin Sulfate Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2018 Document type: Article Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Multiprotein Complexes / Neurturin / Glial Cell Line-Derived Neurotrophic Factor Receptors / Heparitin Sulfate Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2018 Document type: Article Country of publication: United States