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Cross-protection induced by VA-MENGOC-BC® vaccine.
Ochoa-Azze, Rolando Felipe.
Affiliation
  • Ochoa-Azze RF; a Department of Immunology , Institute of Basic and Preclinical Sciences, University of Medical Sciences, Senior Researcher at the Finlay Institute of Vaccines , Havana , Cuba.
Hum Vaccin Immunother ; 14(5): 1064-1068, 2018 05 04.
Article in En | MEDLINE | ID: mdl-29420119
I would like to comment on the article "Commentary: Impact of meningococcal group B OMV vaccines, beyond their brief", DOI: 10.1080/21645515.2017.1381810. The author states that meningococcal group B OMVs vaccines -such as VA-MENGOC-BC®- may induce moderate protection against Neisseria gonorrhoeae. I agree. However, the author states that "there was no evidence of effectiveness in the younger children." The effectiveness of VA-MENGOC-BC® in heterologous contexts has been higher than 80% in individuals older than 4 years old, but the effectiveness in younger children should not be undervalued; it has usually been higher than 60%, and results markedly higher when evaluated based on mortality rates. There is strong evidence that VA-MENGOC-BC® may induce cross-protection against heterologous N. meningitidis strains and N. gonorrhoeae.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Meningococcal Vaccines Limits: Child / Child, preschool / Humans Language: En Journal: Hum Vaccin Immunother Year: 2018 Document type: Article Affiliation country: Cuba Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Meningococcal Vaccines Limits: Child / Child, preschool / Humans Language: En Journal: Hum Vaccin Immunother Year: 2018 Document type: Article Affiliation country: Cuba Country of publication: United States