Alanine and Lysine Scans of the LL-37-Derived Peptide Fragment KR-12 Reveal Key Residues for Antimicrobial Activity.

Gunasekera, Sunithi; Muhammad, Taj; Strömstedt, Adam A; Rosengren, K Johan; Göransson, Ulf

Gunasekera, Sunithi; Muhammad, Taj; Strömstedt, Adam A; Rosengren, K Johan; Göransson, Ulf.

Affiliation

Gunasekera S; Pharmacognosy, Department of Medicinal Chemistry, Uppsala University, Biomedical Centre, Box 574, 75123, Uppsala, Sweden.
Muhammad T; Pharmacognosy, Department of Medicinal Chemistry, Uppsala University, Biomedical Centre, Box 574, 75123, Uppsala, Sweden.
Strömstedt AA; Pharmacognosy, Department of Medicinal Chemistry, Uppsala University, Biomedical Centre, Box 574, 75123, Uppsala, Sweden.
Rosengren KJ; The University of Queensland, School of Biomedical Sciences, Brisbane, QLD, 4072, Australia.
Göransson U; Pharmacognosy, Department of Medicinal Chemistry, Uppsala University, Biomedical Centre, Box 574, 75123, Uppsala, Sweden.

Chembiochem ; 19(9): 931-939, 2018 05 04.

Article in En | MEDLINE | ID: mdl-29430821

Subject(s)

Anti-Infective Agents/chemistry; Anti-Infective Agents/pharmacology; Antimicrobial Cationic Peptides/chemistry; Antimicrobial Cationic Peptides/pharmacology; Cathelicidins/chemistry; Cathelicidins/pharmacology; Peptide Fragments/chemistry; Peptide Fragments/pharmacology; Alanine/chemistry; Alanine/genetics; Alanine/pharmacology; Alanine/toxicity; Amino Acid Sequence; Amino Acid Substitution; Anti-Infective Agents/metabolism; Anti-Infective Agents/toxicity; Antimicrobial Cationic Peptides/genetics; Antimicrobial Cationic Peptides/toxicity; Candida albicans/drug effects; Cathelicidins/genetics; Cathelicidins/toxicity; Cell Line; Cell Survival/drug effects; Humans; Lysine/chemistry; Lysine/genetics; Lysine/pharmacology; Lysine/toxicity; Microbial Sensitivity Tests; Models, Molecular; Peptide Fragments/genetics; Peptide Fragments/toxicity; Pseudomonas aeruginosa/drug effects; Staphylococcus aureus/drug effects

Key words

antibiotics; cytotoxicity; drug discovery; peptides; structure-activity relationships

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Antimicrobial Cationic Peptides / Cathelicidins / Anti-Infective Agents Limits: Humans Language: En Journal: Chembiochem Journal subject: BIOQUIMICA Year: 2018 Document type: Article Affiliation country: Sweden Country of publication: Germany

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