Phosphorylated immunoreceptor tyrosine-based activation motifs and integrin cytoplasmic domains activate spleen tyrosine kinase via distinct mechanisms.

Antenucci, Lina; Hytönen, Vesa P; Ylänne, Jari

Antenucci, Lina; Hytönen, Vesa P; Ylänne, Jari.

Affiliation

Antenucci L; Department of Biological and Environmental Science and Nanoscience Center, University of Jyväskylä, Survontie 9 C, 40014 Jyväskylä, Finland. Electronic address: lina.antenucci@jyu.fi.
Hytönen VP; Faculty of Medicine and Life Sciences and BioMediTech, University of Tampere, and Fimlab Laboratories, Tampere 33014, Finland.
Ylänne J; Department of Biological and Environmental Science and Nanoscience Center, University of Jyväskylä, Survontie 9 C, 40014 Jyväskylä, Finland.

J Biol Chem ; 293(13): 4591-4602, 2018 03 30.

Article in En | MEDLINE | ID: mdl-29440271

Subject(s)

Integrins/chemistry; Peptides/chemistry; Syk Kinase/chemistry; Amino Acid Motifs; Amino Acid Substitution; Enzyme Activation; Humans; Integrins/genetics; Integrins/metabolism; Mutation, Missense; Peptides/genetics; Peptides/metabolism; Phosphorylation; Protein Domains; Syk Kinase/genetics; Syk Kinase/metabolism

Key words

cell signaling; enzyme kinetics; integrin; spleen tyrosine kinase (Syk); surface plasmon resonance (SPR)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Integrins / Syk Kinase Limits: Humans Language: En Journal: J Biol Chem Year: 2018 Document type: Article Country of publication: United States

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