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DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade.
Touat, Mehdi; Sourisseau, Tony; Dorvault, Nicolas; Chabanon, Roman M; Garrido, Marlène; Morel, Daphné; Krastev, Dragomir B; Bigot, Ludovic; Adam, Julien; Frankum, Jessica R; Durand, Sylvère; Pontoizeau, Clement; Souquère, Sylvie; Kuo, Mei-Shiue; Sauvaigo, Sylvie; Mardakheh, Faraz; Sarasin, Alain; Olaussen, Ken A; Friboulet, Luc; Bouillaud, Frédéric; Pierron, Gérard; Ashworth, Alan; Lombès, Anne; Lord, Christopher J; Soria, Jean-Charles; Postel-Vinay, Sophie.
Affiliation
  • Touat M; Inserm U981, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
  • Sourisseau T; Département d'Innovation Thérapeutique et d'Essais Précoces (DITEP), Gustave Roussy, Université Paris-Saclay, Villejuif, France.
  • Dorvault N; Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06 UMRS1127, Institut du Cerveau et de la Moelle Epiniere, ICM, Paris, France.
  • Chabanon RM; Inserm U981, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
  • Garrido M; Inserm U981, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
  • Morel D; Inserm U981, ATIP-Avenir Team, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
  • Krastev DB; Inserm U981, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
  • Bigot L; Inserm U981, ATIP-Avenir Team, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
  • Adam J; Inserm U981, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
  • Frankum JR; Inserm U981, ATIP-Avenir Team, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
  • Durand S; Inserm U981, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
  • Pontoizeau C; Inserm U981, ATIP-Avenir Team, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
  • Souquère S; The CRUK Gene Function Laboratory and Breast Cancer Now Research Centre, The Institute of Cancer Research, London, United Kingdom.
  • Kuo MS; Inserm U981, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
  • Sauvaigo S; Inserm U981, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
  • Mardakheh F; Département de Biologie et Pathologies Médicales, and.
  • Sarasin A; The CRUK Gene Function Laboratory and Breast Cancer Now Research Centre, The Institute of Cancer Research, London, United Kingdom.
  • Olaussen KA; Metabolomics Platform, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
  • Friboulet L; Centre de Référence des Maladies Héréditaires du Métabolisme, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.
  • Bouillaud F; Service de Biochimie Métabolomique et Protéomique, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.
  • Pierron G; Inserm U1163, Institut Imagine, Equipe "Génétique des Maladies Mitochondriales" and Paris Descartes University, Paris, France.
  • Ashworth A; CNRS UMR-9196, Functional Organization of the Cell, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
  • Lombès A; Inserm U981, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
  • Lord CJ; LXRepair, Grenoble, France.
  • Soria JC; Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.
  • Postel-Vinay S; CNRS UMR-8200, Laboratory of Genetic Stability and Oncogenesis, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
J Clin Invest ; 128(4): 1671-1687, 2018 04 02.
Article in En | MEDLINE | ID: mdl-29447131
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Non-Small-Cell Lung / DNA Repair / Lung Neoplasms / NAD / Neoplasms, Experimental Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Clin Invest Year: 2018 Document type: Article Affiliation country: France Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Non-Small-Cell Lung / DNA Repair / Lung Neoplasms / NAD / Neoplasms, Experimental Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Clin Invest Year: 2018 Document type: Article Affiliation country: France Country of publication: United States