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NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction.
Gaude, Edoardo; Schmidt, Christina; Gammage, Payam A; Dugourd, Aurelien; Blacker, Thomas; Chew, Sew Peak; Saez-Rodriguez, Julio; O'Neill, John S; Szabadkai, Gyorgy; Minczuk, Michal; Frezza, Christian.
Affiliation
  • Gaude E; Medical Research Council Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK.
  • Schmidt C; Medical Research Council Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK.
  • Gammage PA; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, UK.
  • Dugourd A; Joint Research Centre for Computational Biomedicine, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
  • Blacker T; Research Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK.
  • Chew SP; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 2QH, UK.
  • Saez-Rodriguez J; Joint Research Centre for Computational Biomedicine, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
  • O'Neill JS; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 2QH, UK.
  • Szabadkai G; Research Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK; Department of Biomedical Sciences, University of Padua and CNR Neuroscience Institute, Padua 35121, Italy; The Francis Crick Institute, Midland Road, London NW1 1AT, UK.
  • Minczuk M; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, UK.
  • Frezza C; Medical Research Council Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK. Electronic address: cf366@mrc-cu.cam.ac.uk.
Mol Cell ; 69(4): 581-593.e7, 2018 02 15.
Article in En | MEDLINE | ID: mdl-29452638
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteosarcoma / Cytosol / Glutamine / Malate Dehydrogenase / Mitochondria / NAD Limits: Female / Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2018 Document type: Article Affiliation country: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteosarcoma / Cytosol / Glutamine / Malate Dehydrogenase / Mitochondria / NAD Limits: Female / Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2018 Document type: Article Affiliation country: United kingdom