Nutraceuticals as therapeutic agents for atherosclerosis.
Biochim Biophys Acta Mol Basis Dis
; 1864(5 Pt A): 1562-1572, 2018 May.
Article
in En
| MEDLINE
| ID: mdl-29454074
ABSTRACT
Atherosclerosis, a chronic inflammatory disorder of medium and large arteries and an underlying cause of cardiovascular disease (CVD), is responsible for a third of all global deaths. Current treatments for CVD, such as optimized statin therapy, are associated with considerable residual risk and several side effects in some patients. The outcome of research on the identification of alternative pharmaceutical agents for the treatment of CVD has been relatively disappointing with many promising leads failing at the clinical level. Nutraceuticals, products from food sources with health benefits beyond their nutritional value, represent promising agents in the prevention of CVD or as an add-on therapy with current treatments. This review will highlight the potential of several nutraceuticals, including polyunsaturated fatty acids, flavonoids and other polyphenols, as anti-CVD therapies based on clinical and pre-clinical mechanism-based studies.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Flavonoids
/
Dietary Supplements
/
Atherosclerosis
/
Fatty Acids, Unsaturated
/
Polyphenols
Limits:
Animals
/
Humans
Language:
En
Journal:
Biochim Biophys Acta Mol Basis Dis
Year:
2018
Document type:
Article
Affiliation country:
United kingdom