Loving the poison: the methylcitrate cycle and bacterial pathogenesis.
Microbiology (Reading)
; 164(3): 251-259, 2018 03.
Article
in En
| MEDLINE
| ID: mdl-29458664
ABSTRACT
Propionate is an abundant catabolite in nature and represents a rich potential source of carbon for the organisms that can utilize it. However, propionate and propionate-derived catabolites are also toxic to cells, so propionate catabolism can alternatively be viewed as a detoxification mechanism. In this review, we summarize recent progress made in understanding how prokaryotes catabolize propionic acid, how these pathways are regulated and how they might be exploited to develop novel antibacterial interventions.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Propionates
/
Bacteria
/
Gene Expression Regulation, Bacterial
/
Citrates
Type of study:
Etiology_studies
Language:
En
Journal:
Microbiology (Reading)
Journal subject:
MICROBIOLOGIA
Year:
2018
Document type:
Article
Affiliation country:
United kingdom