Time-lapse imaging points towards a non-toxic, mainly immune-driven mode of action of ingenol mebutate in the treatment of anogenital warts.
Exp Dermatol
; 27(6): 675-677, 2018 06.
Article
in En
| MEDLINE
| ID: mdl-29461668
ABSTRACT
Recently, it has been reported that ingenol mebutate (IM) is an effective treatment option for anogenital warts (AGW), inducing fast wart necrosis within 24 hours in vivo. With regard to its mode of action, IM is thought to act both as an inducer of direct cytotoxic effects and immunologic mechanisms. To distinguish whether the wart necrosis is mainly caused by cytotoxic effects, or whether immune mechanisms are leading, we used time-lapse imaging to analyse IM-treated warts ex vivo over 24 hours. Ex vivo IM-treated warts, which have been detached from the immune system, did not show destructive necrosis, pointing towards a primarily immune-driven mode of action of IM in the treatment of AGW.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Condylomata Acuminata
/
Diterpenes
/
Antineoplastic Agents
Limits:
Humans
Language:
En
Journal:
Exp Dermatol
Journal subject:
DERMATOLOGIA
Year:
2018
Document type:
Article
Affiliation country:
Germany