The search for new antithrombotic mechanisms and therapies that may spare hemostasis.
Blood
; 131(17): 1899-1902, 2018 04 26.
Article
in En
| MEDLINE
| ID: mdl-29467183
ABSTRACT
Current antithrombotic drugs, including widely used antiplatelet agents and anticoagulants, are associated with significant bleeding risk. Emerging experimental evidence suggests that the molecular and cellular mechanisms of hemostasis and thrombosis can be separated, thereby increasing the possibility of new antithrombotic therapeutic targets with reduced bleeding risk. We review new coagulation and platelet targets and highlight the interaction between integrin αMß2 (Mac-1, CD11b/CD18) on leukocytes and GPIbα on platelets that seems to distinguish thrombosis from hemostasis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thrombosis
/
Drug Discovery
/
Fibrinolytic Agents
/
Hemorrhage
/
Hemostasis
Limits:
Animals
/
Humans
Language:
En
Journal:
Blood
Year:
2018
Document type:
Article